Easy Scale-down

Ion Exchange Chromatography Units Mustang XT Acrodisc

24.04.2012 Mustang XT Acrodisc units from Pall, available in Q and S chemistries, are suitable for scale-down process development work in a variety of downstream process applications.

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Ion Exchange Chromatography Units Mustang XT Acrodisc

The adsorption apparatus is suitable for scale-down process development work in a variety of downstream process applications (Picture: Pall)

A membrane volume of < 1 ml reduces the amount of sample required for evaluation, and the female luer lock inlet and outlet simplifies connection to typical low pressure chromatography systems. The open pore structure eliminates diffusion limitations of conventional macroporous sorbents, allowing biomolecules to access all binding sites by convective flow. In addition, the large pores eliminate size exclusion effects and allow full access to the binding chemistry for very large proteins, plasmids, and viruses. Each unit contains 16 layers of Mustang membrane, the same as the larger Mustang units, allowing accurate scale-up from process development to pilot and process scale, especially with regard to flow/differential pressure and dynamic binding capacity. The units are manufactured in accordance with 21 CFR Part 820, Quality System Requirements, and consist of fully traceable raw components.

Achema 2012 Hall 5.0 – D34

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