DSP – Purification of Biomolecules

In manufacturing of amino acids, peptides, proteins and monoclonal antibodies 50-90 % of the Cost of Goods (COG) are caused by Downstream Processing. In process development separation processes must be proposed in an efficient sequence based on physico-chemical properties of target molecules, contaminants, side components and impurities to increase yield/recovery, and meet the needed product purity and quality while simultaneously reducing the number of unit operations involved.

Learn different design methods as well as scale up of Downstream Processing for complex molecules with exemplary industrial applications to render your process more efficient and thereby more economic.

The content of the course will be presented in lectures with the opportunity for discussion. Basic knowledge will be deepened interactively with the aid of examples in interactive tutorials.

An experimental introduction in the laboratories into membrane, membrane adsorber and chromatography equipment as well as extraction, crystallization/precipitation, lyophilization and distillation will be provided.

Process design will be explained, at first theoretically and afterwards deepened by interactive simulation tutorials.